pSAE

Percent Solvent‑Accessible Exposed hydrophobicity (and related exposure metrics)

pSAE denotes exposure‑based heuristics (e.g., percent of solvent‑accessible exposed hydrophobic surface or residues) used to estimate aggregation risk.

• Type: Exposure metric (solvent‑accessible hydrophobic exposure)
• Goal: Identify/flag aggregation‑prone designs
• Input: 3D structure or predicted SASA; sequence‑derived proxies (hydropathy windows)

Notes: Implementations vary across toolkits; ensure consistent residue/burial definitions.