Human PD-1
Programmed cell death protein 1 (PD-1) is a cell surface receptor that plays a critical role in regulating the immune system.
Function
Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor that belongs to the immunoglobulin superfamily. It is expressed on T cells, B cells, and monocytes and is a potent regulator of immune responses. PD-1 and its ligands are a promising therapeutic target for a variety of cancers.
Structure
Human PD-1 has an immunoglobulin variable-like (IgV) domain structure that is characteristic of immune checkpoint receptors. The protein’s structure reveals important binding interfaces with its ligands PD-L1 and PD-L2, which are critical for understanding immune regulation mechanisms.
Target Details
Protein Information
Protein Information
Organism: Homo sapiens (Human) Gene Name: PDCD1 Alternative Names: CD279, programmed cell death 1 Protein Family: Immunoglobulin superfamily, immune checkpoint receptors
Database References
Database References
UniProt ID: Q15116 Gene ID: 5133 NCBI Reference: Q15116 Protein Region: Leu 25 - Gln 167 (extracellular domain)
Structural Information
Structural Information
Molecular Weight: ~32 kDa (full-length), ~16 kDa (extracellular domain) Structure: Immunoglobulin variable-like (IgV) domain Key Features: Signal peptide, IgV domain, transmembrane region, cytoplasmic tail with ITIM and ITSM motifs PDB Structures: Multiple structures available including 4ZQK (PD-1/PD-L1 complex)