Human HER2
Human Epidermal Growth Factor Receptor 2 (HER2) is a protein that plays a key role in the development of several types of cancer.
Function
Human Epidermal Growth Factor Receptor 2 (HER2), also known as ErbB2, is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It is involved in signal transduction pathways that regulate cell growth, survival, and differentiation. Overexpression of HER2 is a key driver in the development and progression of certain aggressive types of breast cancer and other cancers.
Structure
Human HER2 has a similar overall structure to other ErbB family members, with an extracellular domain, transmembrane region, and intracellular kinase domain. The extracellular domain contains multiple subdomains that are important for dimerization and interaction with therapeutic antibodies like trastuzumab (Herceptin).
Target Details
Protein Information
Protein Information
Organism: Homo sapiens (Human) Gene Name: ERBB2 Alternative Names: HER2, ErbB2, neu Protein Family: ErbB family receptor tyrosine kinases
Database References
Database References
UniProt ID: P04626 Gene ID: 2064 NCBI Reference: P04626-1 Protein Region: Thr 23 - Thr 652 (extracellular domain)
Structural Information
Structural Information
Molecular Weight: ~185 kDa (full-length), ~68 kDa (extracellular domain) Structure: Four extracellular subdomains, transmembrane helix, kinase domain Key Features: Signal peptide, ligand binding domains, dimerization interface, kinase domain PDB Structures: Multiple structures available including 1N8Z (HER2-trastuzumab complex)